53218-U
Supelco
SupelMIP® SPE - Beta-blockers
bed wt. 25 mg, volume 10 mL , (LRC), pk of 50
Description
| Application | A class selective MIP phase for the multi-residue extraction of beta-blockers in water and biological fluids. SupelMIP - Beta-blockers was developed for the selective extaction of a broad range of beta-blockers such as altenolol, betaxolol, carazolol,metroprolol, pindolol, propanolol, sotalol and timolol, and others. The SupelMIP cartridge offers excellent reproducibility for surveillance of this common class of drugs of abuse. Loading capacity is superior to immuno-affinity columns, and MS-detection is recommended for forensic validity. Detailed extraction protocols are included with the product. The methods are highly reproducible and offer beta-blocker recoveries of > 80%. The method minimizes matrix effects and offers limits of detection of less than 5 ppt in water and less than 10 ppt for plasma and urine. |
| Features and Benefits | • Highly selective SPE for trace analysis in complex matrices • Achieve lower detection limits • Significant time and cost savings • Improved MS-compatibility |
| General description | SupelMIP SPE phases were developed by MIP Technologies AB, which is one of the leading authorities and commercial pioneers of molecular imprinted polymers for process scale separations, analytical chromatography, and sample preparation. The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest. By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection. Visit www.sigma-aldrich.com/supelmip to learn more. |
| Legal Information | SupelMIP is a registered trademark of Sigma-Aldrich Biotechnology LP and Sigma-Aldrich Co. |
Properties
| composition | bed wt., 25 mg |
| packaging | pk of 50 |
| volume | 10 mL , (LRC) |
